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Article

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

Science translational medicine - 23 Nov 2016

Dey Devaveena, Bagarova Jana, Hatsell Sarah J, Armstrong Kelli A, Huang Lily, Ermann Joerg, Vonner Ashley J, Shen Yue, Mohedas Agustin H, Lee Arthur, Eekhoff Elisabeth M W, van Schie Annelies, Demay Marie B, Keller Charles, Wagers Amy J, Economides Aris N, Yu Paul B

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO) syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I receptor ACVR1, manifests with progressive ossification of skeletal muscles, tendons, ligaments, and joints. In this disease, HO can occur in discrete flares, often triggered by injury or inflammation, or may progress incrementally without...

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Source

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Identifiers

PMID: 27881824
DOI: 10.1126/scitranslmed.aaf1090
PMCID: PMC6407419

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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