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Article

Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution

22 Nov 2022

Abstract excerpt

Objectives Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and Thy1+ connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin and relationship with adult progenitors. Methods To discriminate between Gdf5-lineage cells deriving from the embryonic joint interzone and other Pdgfrα-expressing fibroblasts and progenitors, adult...

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PMID: 36414376
DOI: 10.1136/ard-2021-221682

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