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Article

Deep Learning links TP53 genotype to expression-defined transcriptional program in Acute Myeloid Leukemia

2025-11-12

Abstract excerpt

Acute myeloid leukemia (AML) is a hematological cancer characterized by genetic diversity and poor clinical outcomes. Among various genetic mutations in AML, TP53 mutations have relatively low prevalence and present very dismal survival rates. While the genetic features of AML are well understood, the transcriptional programs associated with TP53 dysfunction are less clear, especially across different clinical gro...

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Literature Corpus work
f44e7f0d-2aed-5450-b439-f3e40ab59a65
DOI
10.1101/2025.11.10.687690
Open publication

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Deep Learning links TP53 genotype to expression-defined transcriptional program in Acute Myeloid LeukemiaDOI 10.1101/2025.11.10.687690
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