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Article

Identification of key pathways and genes in TP53 mutation acute myeloid leukemia: evidence from bioinformatics analysis

1 Dec 2017

Abstract excerpt

Background: Tumor protein p53 ( TP53 ) mutations are not only a risk factor in acute myeloid leukemia (AML) but also a potential biomarker for individualized treatment options. This study aimed to investigate potential pathways and genes associated with TP53 mutations in adult de novo AML. Methods: An RNA sequencing dataset of adult de novo AML was downloaded from The Cancer Genome Atlas database. Differentially...

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PMID: 29343974
DOI: 10.2147/ott.s156003

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