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Article

Elucidating the immune landscape and potential prognostic model in acute myeloid leukemia with TP53 mutation.

Hematology (Amsterdam, Netherlands) - 1 Dec 2024

Zhu Gelan, Cai Jiayi, Fu Wanbin, Sun Yue, Wang Ting, Zhong Hua

Abstract excerpt

OBJECTIVES: The TP53 mutation, a prevalent tumor suppressor gene alteration, is linked to chemotherapy resistance, increased relapse rates and diminished overall survival (OS) in acute myeloid leukemia (AML) patients. METHODS: In this study, we characterize the TP53 mutation phenotypes across various AML cohorts utilizing The Cancer Genome Atlas (TCGA) data. We devised a TP53-related prognostic signature derived...

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PMID: 39327848
DOI: 10.1080/16078454.2024.2400620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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