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Machine learning investigation of gene expression datasets reveals <i>TP53</i> mutant-like AML with wild type <i>TP53</i> and poor prognosis

2023-02-23

Abstract excerpt

Acute myeloid leukemia (AML) with TP53 mutations ( TP53Mut ) has poor clinical outcomes with 1-year survival rates of less than 10%. We investigated whether this AML subtype harbors a distinct gene expression profiling (GEP), what this GEP reveals about TP53Mut AML pathophysiology, and whether this GEP is prognostic in TP53 wild type ( TP53WT ) AML. We applied a supervised machine-learning approach to assess...

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Literature Corpus work
b8ab5c13-4e22-5e75-b2b0-0c172f4c1295
DOI
10.1101/2023.02.22.529592
Open publication

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Machine learning investigation of gene expression datasets reveals <i>TP53</i> mutant-like AML with wild type <i>TP53</i> and poor prognosisDOI 10.1101/2023.02.22.529592
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