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Machine Learning Analysis of Gene Expression Reveals TP53 Mutant-like AML With Wild Type TP53 And Poor Prognosis

2023-11-10

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) with TP53 mutations (TP53Mut) has poor clinical outcomes. We investigated whether this AML subtype harbors a distinct gene expression profile (GEP) and whether this GEP is prognostic in TP53 wild type (TP53WT) AML. We applied a supervised machine-learning approach to detect the TP53Mut GEP. We divided the samples in the Beat-AML dataset into training and tes...

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Literature Corpus work: b82d9388-27fa-5c1e-bd0d-124592f07042
DOI: 10.21203/rs.3.rs-3575623/v1

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