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Article

Association Analyses of TP53 Mutation With Prognosis, Tumor Mutational Burden, and Immunological Features in Acute Myeloid Leukemia.

Frontiers in immunology - 1 Jan 2021

Wen Xiang-Mei, Xu Zi-Jun, Jin Ye, Xia Pei-Hui, Ma Ji-Chun, Qian Wei, Lin Jiang, Qian Jun

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease related to a broad spectrum of molecular alterations. The successes of immunotherapies treating solid tumors and a deeper understanding of the immune systems of patients with hematologic malignancies have promoted the development of immunotherapies for the treatment of AML. And high tumor mutational burden (TMB) is an emerging predictive biomarker for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Leukemia, Myeloid, Acute

Share to Lymphocytes, Tumor-Infiltrating

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 34745095
DOI: 10.3389/fimmu.2021.717527
PMCID: PMC8566372

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