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Longitudinal decline in striatal DAT binding in LRRK2 Parkinson’s disease: connections with CSF α-Synuclein Seeding Activity

2025-05-21

Abstract excerpt

<h4>Objective</h4> Parkinson’s disease (PD) associated with mutations in the LRRK2 gene exhibits considerable pathological heterogeneity and may not present with Lewy body pathology. The α-Syn seed amplification assay (SAA) performed on cerebrospinal fluid (CSF) has emerged as a reliable in vivo biomarker of α-Syn aggregation. In this study, we aim to investigate the longitudinal trajectories of striatal dopaminer...

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Literature Corpus work
b7afb465-2d96-5b68-bf0d-933f40dd30ba
DOI
10.1101/2025.05.19.25327958
Open publication

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Longitudinal decline in striatal DAT binding in LRRK2 Parkinson’s disease: connections with CSF α-Synuclein Seeding ActivityDOI 10.1101/2025.05.19.25327958
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