Article

Dogcatcher2: Improved statistical detection of transcriptional readthrough and repetitive element analysis across sequencing platforms

2026-05-12

Abstract excerpt

Downstream of Gene (DoG) transcription occurs when RNA polymerase II fails to terminate normally at the transcription end site, resulting in extended transcription downstream of the gene. This is a widespread phenomenon linked to cellular stress, cancer and neurodegeneration. Existing tools for DoG detection from short-read RNA-seq rely on absolute coverage thresholds and sliding window approaches that are sensiti...

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Literature Corpus work: f417fea6-0b49-5ad9-8469-4eccb8d87226
DOI: 10.64898/2026.05.07.723642

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