Article

A phylogeny-guided framework for decoding mechanisms of human endogenous retrovirus regulation in health and disease

2026-05-21

Abstract excerpt

Human endogenous retroviruses (HERVs) are remmants of ancient infections which make up to ∼8% of the human genome. Their activity influences development, immunity, and cancer, but studying them has been limited by a key technical challenge: short-read sequencing cannot uniquely assign reads to these highly repetitive elements. Here, we present ERVmancer, a phylogeny-informed method that resolves the read-mapping a...

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Literature Corpus work: d7b2596d-92d6-5d9b-bb97-1f6c622f85c5
DOI: 10.64898/2026.05.19.726217

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