Article

Coverage landscape of the human genome in nucleus DNA and cell-free DNA

2024-12-07

Abstract excerpt

For long, genome-wide coverage has been used as a measure of sequencing quality and quantity, but the biology hidden beneath has not been fully exploited. Here we performed a comparative analysis on genome-wide coverage profiles between nucleus genome DNA (gDNA) samples from the 1000 Genomes Project (n=3,202) and cell-free DNA (cfDNA) samples from healthy controls (n=113) or cancer patients (n=362). Regardless of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35d7e87f-def8-5b36-a912-5a50a3ddb52d
DOI: 10.1101/2024.12.03.626615

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coverage landscape of the human genome in nucleus DNA and cell-free DNADOI 10.1101/2024.12.03.626615Read

Integrated analysis toolkit for dissecting whole‐genome‐wide features of cell‐free DNASemantic proximity Read

Cell-Free DNA Provides a Good Representation of the Tumor Genome Despite Its Biased Fragmentation PatternsSemantic proximity Read

Cell type signatures in cell-free DNA fragmentation profiles reveal disease biologySemantic proximity Read

CRAG: <i>De novo</i> characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencingSemantic proximity Read

Leveraging sequences missing from the human genome to diagnose cancerSemantic proximity Read

A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNASemantic proximity Read

cfDNA UniFlow: A unified preprocessing pipeline for cell-free DNA data from liquid biopsiesSemantic proximity Read

Exploration of Coding and Non-coding Variants in Cancer Using GenomePaint.Semantic proximity Read

FinaleDB: a browser and database of cell-free DNA fragmentation patternsSemantic proximity Read

Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA.Semantic proximity Read

Human Body Single-Cell Atlas of 3D Genome Organization and DNA MethylationSemantic proximity Read

Index and biological spectrum of accessible DNA elements in the human genomeSemantic proximity Read