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Cross species modeling reveals a role for the unfolded protein response in shaping the transcriptional reaction to <i>Mycobacterium tuberculosis</i> infection

2024-04-24

Abstract excerpt

Numerous blood mRNA signatures have been developed to diagnose tuberculosis (TB) disease. The utility of these signatures in diverse populations depends on the inclusion of ubiquitously expressed features, such as type 1 interferon (IFN) production and innate immune cell activities. As a result, these signatures are generally insensitive to heterogeneous responses between individuals. Designing more effective ther...

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Identifiers and source

Literature Corpus work
a154cf04-cdad-542e-8652-336c6aefe159
DOI
10.1101/2024.04.19.590290
Open publication

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Cross species modeling reveals a role for the unfolded protein response in shaping the transcriptional reaction to <i>Mycobacterium tuberculosis</i> infectionDOI 10.1101/2024.04.19.590290
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