Article

An Inter-Species Translation Model Implicates Integrin Signaling in Infliximab-Resistant Colonic Crohn’s Disease

2019-09-23

Abstract excerpt

Anti-TNF therapy resistance is a major clinical challenge in Crohn’s Disease (CD), partly due to insufficient understanding of disease-site, protein-level mechanisms of CD and anti-TNF treatment resistance. Although some proteomics data from CD mouse models exists, data type and phenotype discrepancies contribute to confounding attempts to translate between preclinical animal models of disease and human clinical c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60f2aa3b-321b-530c-8ca5-b9321486456a
DOI: 10.1101/776666

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Inter-Species Translation Model Implicates Integrin Signaling in Infliximab-Resistant Colonic Crohn’s DiseaseDOI 10.1101/776666Read

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammationSemantic proximity Read

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel diseaseSemantic proximity Read

Integrated multi-model analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBDSemantic proximity Read

Cross species modeling reveals a role for the unfolded protein response in shaping the transcriptional reaction to <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read

Computational Translation of Mouse Models of Osteoarthritis Predicts Human DiseaseSemantic proximity Read

Cross-Species Translation Enhances the Use of Mouse Models for Translatability and Drug Discovery in Late-Onset Alzheimer’s DiseaseSemantic proximity Read

Cytokine interaction networks, not individual cytokines, drive anti-TNF response in Crohn’s diseaseSemantic proximity Read

Conserved transcriptomic profile between mouse and human colitis allows temporal dynamic visualization of IBD-risk genes and unsupervised patient stratificationSemantic proximity Read

Systems biology-driven miR-mRNA integration identifies potential steroid- refractoriness biomarkers in ulcerative colitis and reveals a conserved mechanism across speciesSemantic proximity Read

Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratificationSemantic proximity Read

A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients.Semantic proximity Read

Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel diseaseSemantic proximity Read