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Article

Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease.

PloS one - 1 Jan 2024

Gammie Stephen C, Messing Albee, Hill Mason A, Kelm-Nelson Cynthia A, Hagemann Tracy L

Abstract excerpt

Alzheimer's disease (AD) is a complex neurodegenerative disorder with both genetic and non-genetic causes. Animal research models are available for a multitude of diseases and conditions affecting the central nervous system (CNS), and large-scale CNS gene expression data exist for many of these. Although there are several models specifically for AD, each recapitulates different aspects of the human disease. In...

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Source

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Identifiers

PMID: 38236817
DOI: 10.1371/journal.pone.0291995
PMCID: PMC10796008

Genes

APP
GFAP
PSEN1
ATG7
CSTB
GRID2
INSM1
MAPT
TYROBP
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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