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Translating Brain Anatomy and Disease from Mouse to Human in Latent Gene Expression Space

2025-04-01

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> The mouse model is the most widely used animal model in neuroscience, yet translating findings to humans suffers from the lack of formal models comparing the mouse and the human brain. Here, we devised a novel framework using mouse and human gene expression to build a quantitative common space and apply it to models of neurodegenerative disease. <h4>Methods</h4> We trained a...

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Literature Corpus work
2a727ec5-b3ef-5cd2-a43b-ec60bb9a274a
DOI
10.1101/2025.03.31.646307
Open publication

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Translating Brain Anatomy and Disease from Mouse to Human in Latent Gene Expression SpaceDOI 10.1101/2025.03.31.646307
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