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Article

Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling.

Neuron - 2 Dec 2015

Bornstein Bavat, Zahavi Eitan Erez, Gelley Sivan, Zoosman Maayan, Yaniv Shiri Penina, Fuchs Ora, Porat Ziv, Perlson Eran, Schuldiner Oren

Abstract excerpt

Developmental axon pruning is essential for normal brain wiring in vertebrates and invertebrates. How axon pruning occurs in vivo is not well understood. In a mosaic loss-of-function screen, we found that Bsk, the Drosophila JNK, is required for axon pruning of mushroom body γ neurons, but not their dendrites. By combining in vivo genetics, biochemistry, and high-resolution microscopy, we demonstrate that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26586184
DOI: 10.1016/j.neuron.2015.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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