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Article

UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.

Current biology : CB - 18 Sept 2007

Jospin Maelle, Watanabe Shigeki, Joshi Deepa, Young Sean, Hamming Kevin, Thacker Colin, Snutch Terrance P, Jorgensen Erik M, Schuske Kim

Abstract excerpt

Synaptojanin is a lipid phosphatase required to degrade phosphatidylinositol 4,5 bisphosphate (PIP(2)) at cell membranes during synaptic vesicle recycling. Synaptojanin mutants in C. elegans are severely uncoordinated and are depleted of synaptic vesicles, possibly because of accumulation of PIP(2). To identify proteins that act downstream of PIP(2) during endocytosis, we screened for suppressors of synaptojanin...

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Source

Identifiers

PMID: 17825559
DOI: 10.1016/j.cub.2007.08.036

Genes

PIP
NALCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.PMID 17825559Read ↗

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