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Mechanisms of Weight Control by Primary Cilia

1 Apr 2022

Abstract excerpt

A primary cilium, a hair-like protrusion of the plasma membrane, is a pivotal organelle for sensing external environmental signals and transducing intracellular signaling. An interesting linkage between cilia and obesity has been revealed by studies of the human genetic ciliopathies Bardet-Biedl syndrome and Alström syndrome, in which obesity is a principal manifestation. Mouse models of cell type-specific cilia...

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PMID: 35387896
DOI: 10.14348/molcells.2022.2046

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