Article

The primary cilium is required for MC4R control of food intake and body weight

2020-11-15

Abstract excerpt

The Melanocortin-4 Receptor (MC4R) plays a critical role in the long-term regulation of energy homeostasis and mutations in MC4R are the most common cause of monogenic obesity. However, the precise molecular and cellular mechanisms underlying the maintenance of energy balance within MC4R expressing neurons are unknown. We recently reported that MC4R localizes to primary cilia, a cellular organelle that allows for...

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Identifiers and source

Literature Corpus work: 638da826-d458-50ec-9e4c-8c34a1297150
DOI: 10.1101/2020.11.13.382234

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