Article

Synaptic gene expression changes in frontotemporal dementia due to the<i>MAPT</i>10+16 mutation

2024-04-12

Abstract excerpt

Mutations in the MAPT gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with Parkinsonism). In Alzheimer’s disease, the most common tauopathy, synapse loss is the strongest pathological correlate of cognitive decline. Recently, PET imaging with synaptic tracers revealed clinically relevant loss of synapses in primary tauopathies; however,...

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Literature Corpus work: f3cf1b1a-1196-56ca-906e-31c233d8b650
DOI: 10.1101/2024.04.09.24305501

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