Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.

Neuropathology and applied neurobiology - 1 Aug 2024

Dando Owen, McGeachan Robert, McQueen Jamie, Baxter Paul, Rockley Nathan, McAlister Hannah, Prasad Adharsh, He Xin, King Declan, Rose Jamie, Jones Phillip B, Tulloch Jane, Chandran Siddharthan, Smith Colin, Hardingham Giles, Spires-Jones Tara L

Abstract excerpt

AIMS: Mutations in the MAPT gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with Parkinsonism). In Alzheimer's disease, the most common tauopathy, synapse loss is the strongest pathological correlate of cognitive decline. Recently, Positron Emission Tomography (PET) imaging with synaptic tracers revealed clinically relevant loss of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontotemporal Dementia

Share to Gene Expression

Share to Mutation

Share to Synapses

Share to tau Proteins

Share to Tauopathies

Source

Identifiers

PMID: 39164997
DOI: 10.1111/nan.13006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.PMID 39164997Read ↗

Synaptic gene expression changes in frontotemporal dementia due to the<i>MAPT</i>10+16 mutationSemantic proximity Read ↗

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.Semantic proximity Read ↗

Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and ADSemantic proximity Read ↗

Conserved gene signatures shared among <i>MAPT</i> mutations reveal defects in calcium signalingSemantic proximity Read ↗

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signalingSemantic proximity Read ↗

Multi-omic phenotyping of <i>MAPT</i> V337M neurons reveals early changes in axonogenesis and tau phosphorylationSemantic proximity Read ↗

MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsySemantic proximity Read ↗

Dysregulated coordination of <i>MAPT</i> exon 2 and exon 10 splicing underlies different tau pathologies in PSP and ADSemantic proximity Read ↗

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.Semantic proximity Read ↗

Dysregulation of RNA Splicing in TauopathiesSemantic proximity Read ↗

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expressionSemantic proximity Read ↗

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.