Article

Dysregulated coordination of <i>MAPT</i> exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD

2021-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Understanding regulation of MAPT splicing is important to the etiology of many nerurodegenerative diseases, including Alzheimer disease (AD) and progressive supranuclear palsy (PSP), in which different tau isoforms accumulate in pathologic inclusions. MAPT , the gene encoding the tau protein, undergoes complex alternative pre-mRNA splicing to generate six isoforms. Tauopathies can be categoriz...

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Literature Corpus work: 20c512b3-9a5d-58be-a230-d17665e0e80b
DOI: 10.1101/2021.09.23.461598

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