Article

The <i>NORAD</i> -pumilio regulatory axis links lncRNA dysregulation to tau propagation-associated phenotypes

2026-07-03

Abstract excerpt

Long non-coding RNAs (lncRNAs) are increasingly implicated in neurodegenerative disease, yet their roles in tauopathy remain poorly understood. Here, we defined the lncRNA landscape across iPSC-derived neurons, astrocytes, and microglia harboring the frontotemporal dementia-associated MAPT IVS10+16 mutation and investigated how lncRNA dysregulation interfaces with tau pathology. Transcriptomic analyses revealed e...

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Literature Corpus work: b3ca2815-c889-54ec-87c9-c4c96c301e27
DOI: 10.64898/2026.06.30.735697

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