Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy

17 Aug 2024

Abstract excerpt

Progressive supranuclear palsy (PSP) is a neurodegenerative movement and cognitive disorder characterized by abnormal accumulation of the microtubule-associated protein tau in the brain. Biochemically, inclusions in PSP are enriched for tau proteoforms with four microtubule-binding domain repeats (4R), an isoform that arises from alternative tau pre-mRNA splicing. While preferential aggregation and reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to RNA regulation and disease
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39154163
DOI: 10.1186/s40478-024-01839-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsyPMID 39154163Read ↗

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Semantic proximity Read ↗

Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regionsSemantic proximity Read ↗

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration.Semantic proximity Read ↗

Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.Semantic proximity Read ↗

Motor and non-motor features in progressive supranuclear palsy: the impact of microtubule associated protein tau haplotypes among a Tunisian cohort.Semantic proximity Read ↗

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsySemantic proximity Read ↗

High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.Semantic proximity Read ↗

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear PalsySemantic proximity Read ↗

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.Semantic proximity Read ↗

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.Semantic proximity Read ↗

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.Semantic proximity Read ↗

Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.