Article
The crystal structure of yeast mitochondrial type pyrophosphatase provides a model to study pathological mutations in its human ortholog.
Biochemical and biophysical research communications - 17 Dec 2024
Bezpalaya Ekaterina Y, Matyuta Ilya O, Vorobyeva Natalia N, Kurilova Svetlana A, Oreshkov Sergey D, Minyaev Mikhail E, Boyko Konstantin M, Rodina Elena V
Abstract excerpt
Mutations in human ppa2 gene encoding mitochondrial inorganic pyrophosphatase (PPA2) result in the mitochondria malfunction in heart and brain and lead to early death. In comparison with its cytosolic counterpart, PPA2 of any species is a poorly characterized enzyme with a previously unknown 3D structure. We report here the crystal structure of PPA2 from yeast Ogataea parapolymorpha (OpPPA2), as well as its...
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