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NRF-mediated autophagy and UPR: Exploring new avenues to overcome cancer chemo-resistance

18 Dec 2024

Abstract excerpt

The development of chemo-resistance remains a significant hurdle in effective cancer therapy. NRF1 and NRF2, key regulators of redox homeostasis, play crucial roles in the cellular response to oxidative stress, with implications for both tumor growth and resistance to chemotherapy. This study delves into the dualistic role of NRF2, exploring its protective functions in normal cells and its paradoxical support of...

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PMID: 39706466
DOI: 10.1016/j.ejphar.2024.177210

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