Article

Single molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing

2022-06-26

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for characterizing diseases. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to hundreds of millions of reads per cfDNA sample from cancer patients, an order of magnitude improvement over existing nanopore methods. Leveraging methylomes of...

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Literature Corpus work: 5fda9bad-44b9-5429-ae61-1dd1292ccf5f
DOI: 10.1101/2022.06.22.497080

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