Article

High-resolution spatial mapping of cell state and lineage dynamics <i>in vivo</i> with PEtracer

2025-06-15

Abstract excerpt

Charting the spatiotemporal dynamics of cell fate determination in development and disease is a long-standing objective in biology. Here we present the design, development, and extensive validation of PEtracer, a prime editing-based, evolving lineage tracing technology compatible with both single-cell sequencing and multimodal imaging methodologies to jointly profile cell state and lineage in dissociated cells or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b466258f-872e-50ba-9629-33d97ae8d682
DOI: 10.1101/2025.06.15.659774

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-resolution spatial mapping of cell state and lineage dynamics <i>in vivo</i> with PEtracerDOI 10.1101/2025.06.15.659774Read

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT statesSemantic proximity Read

Tracing cellular dynamics in tissue development, maintenance and diseaseSemantic proximity Read

Tracing tumorigenesis in a solid tumor model at single-cell resolutionSemantic proximity Read

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.Semantic proximity Read

Mitochondrial clone tracing within spatially intact human tissuesSemantic proximity Read

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolutionSemantic proximity Read

Mapping single-cell developmental potential in health and disease with interpretable deep learningSemantic proximity Read

Single-cell lineage tracing maps clonal and transcriptional dynamics in melanoma metastasisSemantic proximity Read

Dissecting the mammary gland one cell at a timeSemantic proximity Read

scTOP: physics-inspired order parameters for cellular identification and visualizationSemantic proximity Read

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland DevelopmentSemantic proximity Read

SCAPE: An AI-Driven Platform for Comprehensive Single-Cell Data AnalysisSemantic proximity Read