Article

Control of Androgen Receptor Signaling in Prostate Cancer by the Cochaperone Small Glutamine–Rich Tetratricopeptide Repeat Containing Protein α

2007-10-15

Abstract excerpt

Abstract Although the androgen receptor (AR) is accepted as the major determinant of prostate cancer cell survival throughout disease progression, it is currently unclear how the receptor sustains genomic signaling under conditions of systemic androgen ablation. Here, we show that the evolutionarily conserved Hsp70/Hsp90 cochaperone, small glutamine–rich tetratricopeptide repeat containing protein α (αSGT), intera...

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Literature Corpus work: f3a9d5df-7b40-55fb-9095-6a267dd5e9a3
DOI: 10.1158/0008-5472.can-07-1646

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