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Article

Mutation of the androgen receptor causes oncogenic transformation of the prostate.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2005

Han Guangzhou, Buchanan Grant, Ittmann Michael, Harris Jonathan M, Yu Xiaoqing, Demayo Francesco J, Tilley Wayne, Greenberg Norman M

Abstract excerpt

Recent evidence demonstrates that the androgen receptor (AR) continues to influence prostate cancer growth despite medical therapies that reduce circulating androgen ligands to castrate levels and/or block ligand binding. Whereas the mutation, amplification, overexpression of AR, or cross-talk between AR and other growth factor pathways may explain the failure of androgen ablation therapies in some cases, there...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15657128
DOI: 10.1073/pnas.0408925102
PMCID: PMC544619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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