Article
Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation.
Oncotarget - 12 Jan 2016
Liu Xiaming, Han Weiwei, Gulla Sarah, Simon Nicholas I, Gao Yanfei, Cai Changmeng, Yang Hongmei, Zhang Xiaoping, Liu Jihong, Balk Steven P, Chen Shaoyong
Abstract excerpt
The phosphoprotein phosphatases are emerging as important androgen receptor (AR) regulators in prostate cancer (PCa). We reported previously that the protein phosphatase 1 catalytic subunit (PP1α) can enhance AR activity by dephosphorylating a site in the AR hinge region (Ser650) and thereby decrease AR nuclear export. In this study we show that PP1α increases the expression of wildtype as well as an S650A mutant...
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