Article

Targeting the BAG-1 family of co-chaperones in lethal prostate cancer

2022-10-18

Abstract excerpt

Therapies that abrogate persistent androgen receptor (AR) signaling in castration resistant prostate cancer (CRPC) remain an unmet clinical need. The N-terminal domain (NTD) of the AR drives transcriptional activity in CRPC but is intrinsically disordered and remains a challenging therapeutic target. Therefore, inhibiting critical co-chaperones, such as BAG-1L, is an attractive alternative strategy. We performed d...

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Literature Corpus work: 78e2746a-dedd-5b4c-8ae2-c1e6b2f0a85e
DOI: 10.1101/2022.10.17.512378

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