Article
The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.
The Journal of biological chemistry - 7 Sept 2012
Mukherjee Sarmistha, Cruz-Rodríguez Osvaldo, Bolton Eric, Iñiguez-Lluhí Jorge A
Abstract excerpt
The androgen receptor (AR) mediates the effects of male sexual hormones on development and physiology. Alterations in AR function are central to reproductive disorders, prostate cancer, and Kennedy disease. AR activity is influenced by post-translational modifications, but their role in AR-based diseases is poorly understood. Conjugation by small ubiquitin-like modifier (SUMO) proteins at two synergy control (SC)...
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