Article
Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells.
Molecular and cellular endocrinology - 6 Aug 2011
Buchanan Grant, Need Eleanor F, Barrett Jeffrey M, Bianco-Miotto Tina, Thompson Vanessa C, Butler Lisa M, Marshall Villis R, Tilley Wayne D, Coetzee Gerhard A
Abstract excerpt
The response of prostate cells to androgens reflects a combination of androgen receptor (AR) transactivation and transrepression, but how these two processes differ mechanistically and influence prostate cancer risk and disease outcome remain elusive. Given recent interest in targeting AR transrepressive processes, a better understanding of AR/corepressor interaction and responses is warranted. Here, we used...
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