Article

Analyses of GWAS and sub-threshold loci lead to the discovery of dendrite development and morphology dysfunction underlying schizophrenia genetic risk

2021-03-02

Abstract excerpt

<title>Abstract</title> <p>Schizophrenia (SCZ) is highly polygenic, and thousands of genes contribute to its risk. The 145 GWAS loci identified to date do not fully reveal SCZ genetic risk pathways. In this study, we explore a cost-effective strategy to increase power of inference of novel pathways, by expanding the analysis to include sub-threshold GWAS (subGWAS) loci. We identify 180 subGWAS loci (e.g., 5 x10<s...

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Literature Corpus work: f3a69997-b998-5797-9c66-8d1dd94a3ddd
DOI: 10.21203/rs.3.rs-240477/v1

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