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Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach

13 Jun 2024

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BACKGROUND AND HYPOTHESIS: Investigating the shared brain protein and genetic components of schizophrenia (SCZ) and bipolar I disorder (BD-I) presents a unique opportunity to understand the underlying pathophysiological processes and pinpoint potential drug targets. STUDY DESIGN: To identify overlapping susceptibility brain proteins in SCZ and BD-I, we carried out proteome-wide association studies (PWAS) and...

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Genetic Associations and Epidemiology
Phosphodiesterase function and regulation
Schizophrenia research and treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38869147
DOI: 10.1093/schbul/sbae094

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