Article
Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Oct 2025
Chen Rui, Siciliano Benjamin, Wang Quan, Xu Chongchong, Wei Qiang, Yang Hai, Sutcliffe James S, Jiang Yi, Ji Ying, Liu Chunyu, Cheng Feixiong, Cook Edwin H, Cox Nancy J, Zhong Xue, Wen Zhexing, Li Bingshan
Abstract excerpt
Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost-effective strategy of including sub-threshold GWAS (subGWAS) loci (i.e., 5 × 10-8 < P ≤ 10-6) in analysis is explored to increase the inference power of novel pathways. A total of 180 subGWAS loci are identified from SCZ GWAS studies and are shown to contain substantial true genetic association signals....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.