Article
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development.
Molecular psychiatry - 1 Oct 2022
Liu Dongxin, Zinski Amy, Mishra Akanksha, Noh Haneul, Park Gun-Hoo, Qin Yiren, Olorife Oshoname, Park James M, Abani Chiderah P, Park Joy S, Fung Janice, Sawaqed Farah, Coyle Joseph T, Stahl Eli, Bendl Jaroslav, Fullard John F, Roussos Panos, Zhang Xiaolei, Stanton Patric K, Yin Changhong, Huang Weihua, Kim Hae-Young, Won Hyejung, Cho Jun-Hyeong, Chung Sangmi
Abstract excerpt
Remarkable advances have been made in schizophrenia (SCZ) GWAS, but gleaning biological insight from these loci is challenging. Genetic influences on gene expression (e.g., eQTLs) are cell type-specific, but most studies that attempt to clarify GWAS loci's influence on gene expression have employed tissues with mixed cell compositions that can obscure cell-specific effects. Furthermore, enriched SCZ heritability...
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