Article

Recurring <i>EPHB1</i> mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

2023-03-22

Abstract excerpt

Ephrin (EPH) receptors have been implicated in tumorigenesis and metastasis, but the functional understanding of mutations observed in human cancers is limited. We previously demonstrated reduced cell compartmentalisation for somatic EPHB1 mutations found in metastatic colorectal cancer cases. We, therefore, integrated pan-cancer and pan-EPH mutational data to prioritise recurrent EPHB1 mutations for functional...

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Literature Corpus work: f3a353ef-6779-569a-a15a-aa186409215d
DOI: 10.1101/2023.03.18.533270

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