Article
Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.
Cancer research - 1 Apr 2017
Mathot Lucy, Kundu Snehangshu, Ljungström Viktor, Svedlund Jessica, Moens Lotte, Adlerteg Tom, Falk-Sörqvist Elin, Rendo Verónica, Bellomo Claudia, Mayrhofer Markus, Cortina Carme, Sundström Magnus, Micke Patrick, Botling Johan, Isaksson Anders, Moustakas Aristidis, Batlle Eduard, Birgisson Helgi, Glimelius Bengt, Nilsson Mats, Sjöblom Tobias
Abstract excerpt
The contribution of somatic mutations to metastasis of colorectal cancers is currently unknown. To find mutations involved in the colorectal cancer metastatic process, we performed deep mutational analysis of 676 genes in 107 stages II to IV primary colorectal cancer, of which half had metastasized. The mutation prevalence in the ephrin (EPH) family of tyrosine kinase receptors was 10-fold higher in primary...
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