Article
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.
Cell communication and signaling : CCS - 15 Dec 2023
Kundu Snehangshu, Nunes Luís, Adler Jeremy, Mathot Lucy, Stoimenov Ivaylo, Sjöblom Tobias
Abstract excerpt
BACKGROUND: Ephrin (EPH) receptors have been implicated in tumorigenesis and metastasis, but the functional understanding of mutations observed in human cancers is limited. We previously demonstrated reduced cell compartmentalisation for somatic EPHB1 mutations found in metastatic colorectal cancer cases. We therefore integrated pan-cancer and pan-EPH mutational data to prioritise recurrent EPHB1 mutations for...
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