Article

Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

2023-05-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Ephrin (EPH) receptors have been implicated in tumorigenesis and metastasis, but the functional understanding of mutations observed in human cancers is limited. We previously demonstrated reduced cell compartmentalisation for somatic <italic>EPHB1</italic> mutations found in metastatic colorectal cancer cases. We therefore integrated pan-cancer and pan-EPH mutat...

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Literature Corpus work: c22c552c-fd98-5a0f-9b31-95e675d3c120
DOI: 10.21203/rs.3.rs-2872911/v1

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