Article
Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity.
Communications biology - 6 Aug 2020
Ravasio Andrea, Myaing Myint Z, Chia Shumei, Arora Aditya, Sathe Aneesh, Cao Elaine Yiqun, Bertocchi Cristina, Sharma Ankur, Arasi Bakya, Chung Vin Yee, Greene Adrienne C, Tan Tuan Zea, Chen Zhongwen, Ong Hui Ting, Iyer N Gopalakrishna, Huang Ruby YunJu, DasGupta Ramanuj, Groves Jay T, Viasnoff Virgile
Abstract excerpt
The Eph family of receptor tyrosine kinases is crucial for assembly and maintenance of healthy tissues. Dysfunction in Eph signaling is causally associated with cancer progression. In breast cancer cells, dysregulated Eph signaling has been linked to alterations in receptor clustering abilities. Here, we implemented a single-cell assay and a scoring scheme to systematically probe the spatial organization of...
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