Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms.

Biochemistry - 21 Feb 2012

Lisabeth Erika M, Fernandez Carlos, Pasquale Elena B

Abstract excerpt

The Eph receptor tyrosine kinases make up an important family of signal transduction molecules that control many cellular processes, including cell adhesion and movement, cell shape, and cell growth. All of these are important aspects of cancer progression, but the relationship between Eph receptors and cancer is complex and not fully understood. Genetic screens of tumor specimens from cancer patients have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Disease Progression
Share to Fibronectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Immunoblotting

Share to Protein Conformation

Share to Protein Kinases

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 22242939
DOI: 10.1021/bi2014079
PMCID: PMC3471792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms.PMID 22242939Read ↗

Effects of cancer-associated EPHA3 mutations on lung cancer.Semantic proximity Read ↗

EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic pathways.Semantic proximity Read ↗

Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.Semantic proximity Read ↗

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.Semantic proximity Read ↗

EphA2 Receptor Tyrosine Kinase as a Promising Target for Cancer TherapeuticsSemantic proximity Read ↗

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor roleSemantic proximity Read ↗

Recurring <i>EPHB1</i> mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cellsSemantic proximity Read ↗

Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer.Semantic proximity Read ↗

Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cellsSemantic proximity Read ↗

Molecular Characteristics and Prognostic Role of EPHA2 in Human Tumors via Pan-cancer AnalysisSemantic proximity Read ↗

Eph receptors and ephrins in cancer progressionSemantic proximity Read ↗

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.