Article
Hepatic NADH reductive stress underlies common variation in metabolic traits.
Nature - 1 Jul 2020
Goodman Russell P, Markhard Andrew L, Shah Hardik, Sharma Rohit, Skinner Owen S, Clish Clary B, Deik Amy, Patgiri Anupam, Hsu Yu-Han H, Masia Ricard, Noh Hye Lim, Suk Sujin, Goldberger Olga, Hirschhorn Joel N, Yellen Gary, Kim Jason K, Mootha Vamsi K
Abstract excerpt
The cellular NADH/NAD+ ratio is fundamental to biochemistry, but the extent to which it reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the in vivo application of Lactobacillus brevis (Lb)NOX1, a bacterial water-forming NADH oxidase, to assess the metabolic consequences of directly lowering the hepatic cytosolic NADH/NAD+ ratio in mice. By combining this genetic tool with...
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