Article

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt

2025-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Dihydroxyacetone phosphate (DHAP), glycerol-3-phosphate (Gro3P) and reduced/oxidized nicotinamide adenine dinucleotide (NADH/NAD + ) are key metabolites of the Gro3P shuttle system that forms a redox circuit, allowing transfer of reducing equivalents between cytosol and mitochondria. Targeted activation of Gro3P biosynthesis was recently identified as a promising strategy to alleviate reductive...

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Literature Corpus work: 4e6356e5-61fa-592b-9479-cfa939f4007c
DOI: 10.1101/2025.06.02.657195

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