Article

Adipocyte GDI2 suppresses lipophagy to restrain adaptive thermogenesis and promotes diet-induced obesity

2026-07-06

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Promoting the thermogenic remodeling of white adipose tissue (WAT) is a promising strategy to combat obesity. Lipophagy degrades lipid droplets to supply free fatty acids that fuel thermogenesis in beige adipocytes. GDP dissociation inhibitor 2 (GDI2) is a negative regulator of Rab GTPases implicated in adipocyte lipid storage, but its role in lipophagy-mediat...

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Literature Corpus work: 2fee51b5-4766-5876-839d-884f52c76dcd
DOI: 10.21203/rs.3.rs-10151545/v1

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