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Acute lymphoblastic leukemia displays a distinct highly methylated genome

19 May 2022

Abstract excerpt

DNA methylation is tightly regulated during development and is stably maintained in healthy cells. In contrast, cancer cells are commonly characterized by a global loss of DNA methylation co-occurring with CpG island hypermethylation. In acute lymphoblastic leukemia (ALL), the commonest childhood cancer, perturbations of CpG methylation have been reported to be associated with genetic disease subtype and outcome,...

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PMID: 35590059
DOI: 10.1038/s43018-022-00370-5

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