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DNA methylation-based subtypes of acute myeloid leukemia with distinct prognosis and clinical features

16 Jan 2023

Abstract excerpt

Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage. DNA methylation is an important DNA modification that regulates gene expression. Investigating AML heterogeneity based on DNA methylation could be clinically informative for improving clinical diagnosis and prognosis. The AML subtypes based on DNA methylation were identified by unsupervised consensus clustering. The...

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PMID: 36645547
DOI: 10.1007/s10238-022-00980-4

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